Nitrile hydrolysis
7 real reactions from the literature, on nitriles. Each scheme shows starting materials, conditions and products, with the yield and reference where the source reports them.
Loading examples…
-
Nitrile hydrolysis: 2-methylbenzonitrile with H2SO4; H2O, Δ gives 2-methylbenzoic acid (the carboxylic acid).
-
Nitrile hydrolysis: ethyl 2,4-dicyano-2-phenylbutanoate (a nitrile) with aq. HCl; AcOH, Δ gives 2-phenylpentanedioic acid (the carboxylic acid).
-
Nitrile hydrolysis: 3-butenenitrile with HCl, H2O; Δ gives 3-butenoic acid (the carboxylic acid).
-
Nitrile hydrolysis: 3-aminopropionitrile with Ba(OH)2; H2O, 90 °C gives beta-alanine (the carboxylic acid).
-
Nitrile hydrolysis: sodium cyanoacetate (a nitrile) with aq. NaOH gives disodium malonate (the carboxylate).
-
Nitrile hydrolysis: phenylacetonitrile with HCl, H2O gives benzeneacetamide.
-
Nitrile hydrolysis: glutaronitrile with HCl, H2O; Δ gives glutaric acid (the carboxylic acid).