Acid chloride formation
9 real reactions from the literature, on carboxylic acids. Each scheme shows starting materials, conditions and products, with the yield and reference where the source reports them.
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Acid chloride formation: nicotinic acid (a carboxylic acid) with SOCl2 gives nicotinoyl chloride (the acid chloride).
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Acid chloride formation: monomethyl sebacate (a carboxylic acid) with SOCl2; Δ gives methyl 10-chloro-10-oxodecanoate (the acid chloride).
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Acid chloride formation: butyric acid (a carboxylic acid) with SOCl2; Δ gives butyryl chloride (the acid chloride).
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Acid chloride formation: 4-nitrobenzoic acid (a carboxylic acid) with PCl5, Δ gives 4-nitrobenzoyl chloride (the acid chloride).
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Acid chloride formation: isobutyric acid (a carboxylic acid) with SOCl2 gives isobutyryl chloride (the acid chloride).
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Acid chloride formation: a carboxylic acid with SOCl2; Δ gives the acid chloride.
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Acid chloride formation: cyclohexanecarboxylic acid with SOCl2; Δ gives cyclohexanecarbonyl chloride (the acid chloride).
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Acid chloride formation: itaconic acid (a carboxylic acid) with PCl5 (2 equiv.); Δ gives 2,2-methylenesuccinyl dichloride (the acid chloride).
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Acid chloride formation: O-acetylmandelic acid (a carboxylic acid) with SOCl2 gives 1-(chloroformyl)benzyl acetate (the acid chloride).