Grignard reagent formation
7 real reactions from the literature, on aryl chlorides, primary alkyl bromides, aryl bromides and methyl chlorides. Each scheme shows starting materials, conditions and products, with the yield and reference where the source reports them.
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Grignard formation: chlorobenzene (an aryl chloride) with 1) Mg, iPrOH; 2) HCl, H2O gives benzene (the Grignard reagent).
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Grignard formation: 2-bromomesitylene (an aryl bromide) with Mg; CH3CH2OCH2CH3 gives the Grignard reagent.
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Grignard formation: 1-bromo-2-methylpropane (a primary alkyl bromide) with Mg; CH3CH2OCH2CH3 gives the Grignard reagent.
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Grignard formation: methyl chloride and a Grignard reagent with CH3CH2OCH2CH3; Mg gives the Grignard reagent.
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Grignard formation: butyl bromide (a primary alkyl bromide) with Mg; CH3CH2OCH2CH3 gives the Grignard reagent.
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Grignard formation: 1-bromonaphthalene (a naphthyl bromide) with Mg; CH3CH2OCH2CH3 gives the Grignard reagent.
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Grignard formation: 1-bromo-3-chlorobenzene (an aryl chloride) with Mg; CH3CH2OCH2CH3, Δ gives the Grignard reagent.