Kinetic enolate formation
3 real reactions from the literature, on six-membered cyclic ketones. Each scheme shows starting materials, conditions and products, with the yield and reference where the source reports them.
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Kinetic enolate formation: 2-methylcyclohexanone (a six-membered cyclic ketone) with LDA, DME; − 40-0 °C gives lithium 6-methylcyclohexen-1-olate (the kinetic enolate).
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Kinetic enolate formation: 2-(1,3-benzodioxol-5-yl)cyclohexan-1-one (a six-membered cyclic ketone) with LDA, -78 C gives the kinetic enolate.
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Kinetic enolate formation: 2-methylcyclohexanone (a six-membered cyclic ketone) with 1) 1.05 eq KN(SiMe3)2, -78 C; 2) add BEt3 gives the kinetic enolate.