Strecker synthesis of amino acids
2 real reactions from the literature, on aryl ketones and aromatic aldehydes. Each scheme shows starting materials, conditions and products, with the yield and reference where the source reports them.
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Strecker: acetophenone (an aryl ketone) with 1) NaCN, NH4Cl; H2O, CH3OH; 2) aq. HCl, Δ; 3) pyridine gives 2-amino-2-phenylpropanoic acid (the α-amino acid).
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Strecker: benzaldehyde (an aromatic aldehyde) with 1) NaCN, NH4Cl; H2O, CH3OH; 2) aq. HCl, Δ; 3) NH4OH gives 2-phenylglycine (the α-amino acid).